亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Transcriptional Control of Endothelial Senescence and Vascular Repair

衰老 表观遗传学 生物 细胞衰老 糖尿病 老年学 医学 遗传学 内分泌学 表型 基因
作者
Assam El‐Osta
出处
期刊:Circulation Research [Lippincott Williams & Wilkins]
卷期号:133 (10): 858-860 被引量:1
标识
DOI:10.1161/circresaha.123.323716
摘要

HomeCirculation ResearchVol. 133, No. 10Transcriptional Control of Endothelial Senescence and Vascular Repair No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextTranscriptional Control of Endothelial Senescence and Vascular Repair Assam El-Osta Assam El-OstaAssam El-Osta Correspondence to: Assam El-Osta, PhD, Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, VIC 3004, Australia. Email E-mail Address: [email protected] https://orcid.org/0000-0003-2969-9137 Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Originally published26 Oct 2023https://doi.org/10.1161/CIRCRESAHA.123.323716Circulation Research. 2023;133:858–860This article is a commentary on the followingDisrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial SenescenceFootnotesFor Sources of Funding and Disclosures, see page 860.Correspondence to: Assam El-Osta, PhD, Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, VIC 3004, Australia. Email sam.el-osta@baker.edu.auReferences1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains.Exp Cell Res. 1961; 25:585–621. doi: 10.1016/0014-4827(61)90192-6CrossrefMedlineGoogle Scholar2. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of vascular aging.Circ Res. 2018; 123:849–867. doi: 10.1161/CIRCRESAHA.118.311378LinkGoogle Scholar3. Hammadah M, Al Mheid I, Wilmot K, Ramadan R, Abdelhadi N, Alkhoder A, Obideen M, Pimple PM, Levantsevych O, Kelli HM, et al. Telomere shortening, regenerative capacity, and cardiovascular outcomes.Circ Res. 2017; 120:1130–1138. doi: 10.1161/CIRCRESAHA.116.309421LinkGoogle Scholar4. Al Mheid I, Hayek SS, Ko YA, Akbik F, Li Q, Ghasemzadeh N, Martin GS, Long Q, Hammadah M, Maziar Zafari A, et al. Age and human regenerative capacity impact of cardiovascular risk factors.Circ Res. 2016; 119:801–809. doi: 10.1161/CIRCRESAHA.116.308461LinkGoogle Scholar5. Jiong Hu MSL, Looso M, Drekolia MK, Wittig J, Mettner J, Karantanou C, Kyselova A, Dumbovic G, Li X, Li Y, et al. Disrupted binding of cystathionine 1 γ lyase to p53 promotes endothelial senescence.Circ Res. 2023; 133:842–857. doi: 10.1161/CIRCRESAHA.123.323084LinkGoogle Scholar6. Gulve N, Su C, Deng Z, Soldan SS, Vladimirova O, Wickramasinghe J, Zheng H, Kossenkov AV, Lieberman PM. DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.Nat Commun. 2022; 13:5033. doi: 10.1038/s41467-022-32680-8CrossrefMedlineGoogle Scholar7. Schwartz M, Portugez AS, Attia BZ, Tannenbaum M, Cohen L, Loza O, Chase E, Turman Y, Kaplan T, Salah Z, et al. Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation.Commun Biol. 2020; 3:696. doi: 10.1038/s42003-020-01398-yCrossrefMedlineGoogle Scholar8. Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C. MOZ increases p53 acetylation and premature senescence through its complex formation with PML.Proc Natl Acad Sci USA. 2013; 110:3895–3900. doi: 10.1073/pnas.1300490110CrossrefMedlineGoogle Scholar9. Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.Cell. 1997; 90:595–606. doi: 10.1016/s0092-8674(00)80521-8CrossrefMedlineGoogle Scholar10. Tang Y, Zhao W, Chen Y, Zhao Y, Gu W. Acetylation is indispensable for p53 activation.Cell. 2008; 133:612–626. doi: 10.1016/j.cell.2008.03.025CrossrefMedlineGoogle Scholar11. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, et al. Cystathionine γ lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis.Circulation. 2019; 139:101–114. doi: 10.1161/CIRCULATIONAHA.118.034757LinkGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesDisrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial SenescenceJiong Hu, et al. Circulation Research. 2023;133:842-857 October 27, 2023Vol 133, Issue 10 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.323716PMID: 37883591 Originally publishedOctober 26, 2023 KeywordsEditorialsacetylationagingcellular senescenceepigenomicsheart diseasetelomerasePDF download Advertisement

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
cdercder应助科研通管家采纳,获得10
刚刚
Rita应助科研通管家采纳,获得10
刚刚
cdercder应助科研通管家采纳,获得10
刚刚
刚刚
cdercder应助科研通管家采纳,获得20
刚刚
小二郎应助科研通管家采纳,获得10
刚刚
2秒前
4秒前
5秒前
6秒前
9秒前
11秒前
敏感绿竹发布了新的文献求助10
12秒前
活力的香彤完成签到,获得积分10
13秒前
LI发布了新的文献求助20
13秒前
14秒前
生统小白发布了新的文献求助10
15秒前
Pami发布了新的文献求助10
16秒前
17秒前
Cc完成签到 ,获得积分10
18秒前
19秒前
yaosan完成签到,获得积分10
20秒前
20秒前
22秒前
CodeCraft应助bei采纳,获得10
22秒前
龙傲天发布了新的文献求助10
23秒前
24秒前
lxy完成签到,获得积分10
25秒前
26秒前
27秒前
小蘑菇应助淡定的天问采纳,获得10
29秒前
30秒前
30秒前
32秒前
淡定的天问完成签到 ,获得积分10
33秒前
35秒前
Nizarn发布了新的文献求助10
35秒前
神勇千秋完成签到,获得积分10
36秒前
37秒前
40秒前
高分求助中
On lateral buckling of armouring wires in flexible pipes 10000
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Navigating Normative Orders. Interdisciplinary Perspectives 800
Essentials of Carbohydrate Chemistry and Biochemistry, 4th Edition 700
1 Peter and Christ's Descent to the Dead in Its Early Christian Reception 700
Organizational Behavior 510
Management and the Arts 510
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7744548
求助须知:如何正确求助?哪些是违规求助? 9292384
关于积分的说明 20212592
捐赠科研通 7323264
什么是DOI,文献DOI怎么找? 3307631
关于科研通互助平台的介绍 2459475
邀请新用户注册赠送积分活动 2318555