医学
临床试验
重症监护医学
个性化医疗
代理终结点
精密医学
骨关节炎
替代医学
生物信息学
病理
生物
作者
Ali Mobasheri,Christian S. Thudium,Anne‐Christine Bay‐Jensen,Tazio Maleitzke,Sven Geißler,Georg N. Duda,Tobias Winkler
标识
DOI:10.1016/j.berh.2023.101852
摘要
Osteoarthritis (OA) is the most common form of arthritis globally and a major cause of pain, physical disability, and loss of economic productivity, with currently no causal treatment available. This review article focuses on current research on OA biomarkers and the potential for using biomarkers in future clinical practice and clinical trials of investigational drugs. We discuss how biomarkers, specifically soluble ones, have a long path to go before reaching clinical standards of care. We also discuss how biomarkers can help in phenotyping and subtyping to achieve enhanced stratification and move toward better-designed clinical trials. We also describe how biomarkers can be used for molecular endotyping and for determining the clinical outcomes of investigational cell-based therapies. Biomarkers have the potential to be developed as surrogate end points in clinical trials and help private-public consortia and the biotechnology and pharmaceutical industries develop more effective and targeted personalized treatments and enhance clinical care for patients with OA.
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