小RNA
癌变
癌症
癌症研究
医学
肺癌
膀胱癌
乳腺癌
慢性淋巴细胞白血病
白血病
生物信息学
生物
肿瘤科
基因
免疫学
内科学
遗传学
作者
Soudeh Ghafouri-Fard,Tayyebeh Khoshbakht,Bashdar Mahmud Hussen,Sara Abdullah,Mohammad Taheri,Mohammad Samadian
标识
DOI:10.1186/s12935-022-02754-0
摘要
miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointestinal cancers, lung cancer and bladder cancer. This miRNA has 22 nucleotides. hsa-miR-16-5p is produced by MIR16-1 gene. First evidence for its participation in the carcinogenesis has been obtained by studies reporting deletion and/or down-regulation of these miRNAs in chronic lymphocytic leukemia. Subsequent studies have shown down-regulation of miR-16-5p in a variety of cancer cell lines and clinical samples. Besides, tumor suppressor role of miR-16-5p has been verified in animal models of different types of cancers. Studies in these models have shown that over-expression of this miRNA or modulation of expression of lncRNAs that sponge this miRNA can block carcinogenic processes. In the current review, we summarize function of miR-16-5p in the development and progression of different cancers.
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