Comparison between PRP vs iPRF as an adjunct therapy in Infra-bony Pocket treatment

Background: New materials are being used to enhance, and accelerate healing, of periodontal apparatus. One of these materials is Platelet concentrates which involve two generations platelet rich plasma (PRP), second one is platelet rich fibrin (PRF). Aim: The aim of the present study is to adjunct the healing of intra bony periodontal deep pockets using minimal invasive technique and materials (injectable platelet rich fibrin-I PRF-). Subjects & Method: A total of 70 medically healthy adult subjects with chronic Periodontitis in a Randomized controlled clinical trial were divided into 3 groups; PRP group, iPRF group & control group. PRP preparation:Two Acid citric dextrose (ACD) 8.5 ml tubes of whole blood were centrifuged at 2000 rpm for 7 min at room temperature using Heraeus Megafuge 16R centrifuge. IPRF preparation:Two tubes (without anticoagulant) of 10 ml of whole blood were centrifuged at 700 rpm for 3 min at room temperature using Heraeus Megafuge 16R centrifuge. Postoperative evaluation: The periodontal status for all patients sites were assessed and the data obtained statistically analyzed & results was judged at the 5% level. Results I-PRF group showed the highest reduction of probing depth from baseline, while PRP group came second followed by the control group which had the lowest reduction in probing depth. Conclusion: the repeated injection of i- PRF showing a stronger and more durable effect, since it has number of growth factors which are responsible for tissue regeneration capable of inducing fibroblast behaviour.