挖
化学
分子内力
组合化学
药物化学
立体化学
光化学
万维网
计算机科学
作者
Arun Sharma,Ahhyeon Choi,Daniel Yim,Hyungjun Kim,Hyunwoo Kim
标识
DOI:10.1002/adsc.202400337
摘要
We describe a catalyst, oxidant, and coupling‐reagent free strategy to access 4‐membered heterocycle, representing a unique example of visible‐light triggered intramolecular cyclization of propargylic alcohols and amines to access oxetanones and azetidinones respectively. Despite the direct 4‐endo‐dig cyclization from these starting materials has proven to be unfavorable, the formation of key p‐quinone methide intermediacy allows an efficient bypass for regioselective 4‐exo‐trig cyclization, resulting in the formation of the desired 4‐membered heterocycles. This mild and operationally simple protocol facilitates the synthesis of products with distinct substitution patterns such as quaternary α‐carbons, and enables late‐stage functionalization.
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