性二态性
雄激素
免疫
生物
树突状细胞
细胞生物学
免疫学
免疫系统
内分泌学
激素
作者
Leizi Chi,Can Liu,Inta Gribonika,Julia Gschwend,Dan Corral,Seong-Ji Han,Ai Ing Lim,Claudia A. Rivera,Verena M. Link,Alexandria Wells,Nicolas Bouladoux,Nicholas Collins,Djalma S. Lima-Júnior,Michel Enamorado,Barbara Rehermann,Sophie Laffont,Jean-Charles Guéry,Roxane Tussiwand,Christoph Schneider,Yasmine Belkaid
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-12
卷期号:384 (6692)
标识
DOI:10.1126/science.adk6200
摘要
Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.
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