The squalene route to C30 carotenoid biosynthesis and the origins of carotenoid biosynthetic pathways

角鲨烯 类胡萝卜素 植物烯 生物合成 生物化学 生物 八氢番茄红素脱氢酶 八氢番茄红素合酶 红色红螺菌 萜类 染色体体 萜烯 角鲨烯单加氧酶 化学 质体 叶绿体 基因 番茄红素
作者
Carlos Santana-Molina,Valentina Henriques,Dámaso Hornero‐Méndez,Damien P. Devos,Elena Rivas-Marín
出处
期刊:Proceedings of the National Academy of Sciences of the United States of America [National Academy of Sciences]
卷期号:119 (52) 被引量:10
标识
DOI:10.1073/pnas.2210081119
摘要

Carotenoids are isoprenoid lipids found across the tree of life with important implications in oxidative stress adaptations, photosynthetic metabolisms, as well as in membrane dynamics. The canonical view is that C40 carotenoids are synthesized from phytoene and C30 carotenoids from diapophytoene. Squalene is mostly associated with the biosynthesis of polycyclic triterpenes, although there have been suggestions that it could also be involved in the biosynthesis of C30 carotenoids. However, demonstration of the existence of this pathway in nature is lacking. Here, we demonstrate that C30 carotenoids are synthesized from squalene in the Planctomycetes bacteria and that this squalene route to C30 carotenoids is the most widespread in prokaryotes. Using the evolutionary history of carotenoid and squalene amino oxidases, we propose an evolutionary scenario to explain the origin and diversification of the different carotenoid and squalene-related pathways. We show that carotenoid biosynthetic pathways have been constantly transferred and neofunctionalized during prokaryotic evolution. One possible origin of the squalene pathway connects it with the one of C40 carotenoid synthesis of Cyanobacteria. The widespread occurrence of the squalene route to C30 carotenoids in Bacteria increases the functional repertoire of squalene, establishing it as a general hub of carotenoids and polycyclic triterpenes synthesis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
zzz发布了新的文献求助10
2秒前
白开水完成签到,获得积分10
3秒前
啵啵完成签到 ,获得积分10
5秒前
zzzz完成签到,获得积分20
6秒前
6秒前
研友_8yX0xZ完成签到,获得积分10
7秒前
无敌嘎嘎完成签到,获得积分10
7秒前
Kk完成签到,获得积分10
8秒前
混元形意太极门完成签到,获得积分10
8秒前
ding应助ceci采纳,获得30
11秒前
liubo完成签到,获得积分10
12秒前
我是老大应助okko采纳,获得10
14秒前
TAA66完成签到,获得积分10
16秒前
今后应助河鱼小白脸采纳,获得10
16秒前
宇文无施完成签到,获得积分10
17秒前
完美世界应助JC采纳,获得10
18秒前
十一发布了新的文献求助10
18秒前
19秒前
20秒前
可爱的函函应助扳迪采纳,获得10
22秒前
希望天下0贩的0应助蜉蝣采纳,获得10
23秒前
鸭鸭完成签到,获得积分10
23秒前
yxdeng完成签到 ,获得积分10
25秒前
25秒前
卢不评发布了新的文献求助30
25秒前
27秒前
河鱼小白脸完成签到,获得积分10
28秒前
无敌嘎嘎发布了新的文献求助10
28秒前
烟花应助shiqi采纳,获得10
28秒前
29秒前
30秒前
31秒前
32秒前
32秒前
唯心止论发布了新的文献求助10
32秒前
一枚小豆完成签到,获得积分10
33秒前
33秒前
jzk发布了新的文献求助10
34秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
Brain and Heart The Triumphs and Struggles of a Pediatric Neurosurgeon 400
Cybersecurity Blueprint – Transitioning to Tech 400
Mixing the elements of mass customisation 400
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3785875
求助须知:如何正确求助?哪些是违规求助? 3331226
关于积分的说明 10250759
捐赠科研通 3046728
什么是DOI,文献DOI怎么找? 1672190
邀请新用户注册赠送积分活动 801071
科研通“疑难数据库(出版商)”最低求助积分说明 759979