An Overview of Genome Editing in Cardiovascular and Metabolic Diseases

This chapter summarizes the definition, classification, and function of genome editing and highlights the breakthroughs of genome editing in cardiovascular and metabolic diseases for disease modeling, diagnostics, and therapeutics, with a particular focus on clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated 9 (Cas9) technology as applied to nuclease editing, base editing, and epigenome editing.