The role of the transcription factor PATZ1 in tumorigenesis and metabolic regulation

PATZ1 (POZ/BTB and AT hook containing zinc finger 1) is an important member of the POZ/BTB (Poxvirus and Zinc finger / Broad-complex, Tramtrack, and Bric-à-brac) family and has been confirmed to be involved in the development and progression of various tumors. Moreover, differential expression of PATZ1 is associated with the prognosis of multiple cancers and systemic metabolic patterns. It participates in the regulation of oncogenes and a range of biological processes, including glucose and lipid metabolism. This review aims to summarize the current understanding of the relationship between the transcription factor PATZ1, tumorigenesis, and metabolism, with the goal of providing a theoretical basis for the development of PATZ1-targeted therapies.