The Alpha-Klotho Gene as an Anti-ageing Biomarker: Measures and Applications to the Effects of Nutrition

Ageing is a complex process characterized by a progressive decline of physiological functions, which leads to an impaired physical integrity and an increase of mortality risk. Specifically ageing is influenced by both genetic and environmental factors such as nutrition or physical activity. Recently, different specific ageing biomarkers have been proposed to provide a better insight of the ageing process. One of these new ageing biomarkers is the Klotho gene which encodes different Klotho proteins with anti-ageing physiological and metabolic functions. Therefore, we discuss here the potential mechanisms of the influence of nutrition on S-Klotho levels. Later, we review the current evidence about nutrition and S-Klotho in both preclinical models and humans, as well as future investigation to yield evidence into the influence of nutrition on ageing, specifically on S-Klotho.