Potassium Homeostasis in Health and Disease: A Scientific Workshop Cosponsored by the National Kidney Foundation and the American Society of Hypertension

医学 高钾血症 肾脏疾病 重症监护医学 人口 醛固酮 疾病 肾病科 内科学 环境卫生
作者
Csaba P. Kövesdy,Lawrence J. Appel,Morgan E. Grams,Lisa Gutekunst,Peter A. McCullough,Biff F. Palmer,Bertram Pitt,Dominic A. Sica,Raymond R. Townsend
出处
期刊:American Journal of Kidney Diseases [Elsevier]
卷期号:70 (6): 844-858 被引量:52
标识
DOI:10.1053/j.ajkd.2017.09.003
摘要

While much emphasis, and some controversy, centers on recommendations for sodium intake, there has been considerably less interest in recommendations for dietary potassium intake, in both the general population and patients with medical conditions, particularly acute and chronic kidney disease. Physiology literature and cohort studies have noted that the relative balance in sodium and potassium intakes is an important determinant of many of the sodium-related outcomes. A noteworthy characteristic of potassium in clinical medicine is the extreme concern shared by many practitioners when confronted by a patient with hyperkalemia. Fear of this often asymptomatic finding limits enthusiasm for recommending potassium intake and often limits the use of renin-angiotensin-aldosterone system blockers in patients with heart failure and chronic kidney diseases. New agents for managing hyperkalemia may alter the long-term management of heart failure and the hypertension, proteinuria, and further function loss in chronic kidney diseases. In this jointly sponsored effort between the American Society of Hypertension and the National Kidney Foundation, 3 panels of researchers and practitioners from various disciplines discussed and summarized current understanding of the role of potassium in health and disease, focusing on cardiovascular, nutritional, and kidney considerations associated with both hypo- and hyperkalemia. While much emphasis, and some controversy, centers on recommendations for sodium intake, there has been considerably less interest in recommendations for dietary potassium intake, in both the general population and patients with medical conditions, particularly acute and chronic kidney disease. Physiology literature and cohort studies have noted that the relative balance in sodium and potassium intakes is an important determinant of many of the sodium-related outcomes. A noteworthy characteristic of potassium in clinical medicine is the extreme concern shared by many practitioners when confronted by a patient with hyperkalemia. Fear of this often asymptomatic finding limits enthusiasm for recommending potassium intake and often limits the use of renin-angiotensin-aldosterone system blockers in patients with heart failure and chronic kidney diseases. New agents for managing hyperkalemia may alter the long-term management of heart failure and the hypertension, proteinuria, and further function loss in chronic kidney diseases. In this jointly sponsored effort between the American Society of Hypertension and the National Kidney Foundation, 3 panels of researchers and practitioners from various disciplines discussed and summarized current understanding of the role of potassium in health and disease, focusing on cardiovascular, nutritional, and kidney considerations associated with both hypo- and hyperkalemia. Erratum Regarding “Potassium Homeostasis in Health and Disease: A Scientific Workshop Cosponsored by the National Kidney Foundation and the American Society of Hypertension” (Am J Kidney Dis. 2017;70[6]:844-858)American Journal of Kidney DiseasesVol. 80Issue 5PreviewIn the Special Report entitled “Potassium Homeostasis in Health and Disease: A Scientific Workshop Cosponsored by the National Kidney Foundation and the American Society of Hypertension” that appeared in the December 2017 issue of AJKD (Kovesdy et al, volume 70, issue 6, pages 844-858), there was an error in the financial disclosure statement. The corrected statement is “Financial Disclosure: Dr Kovesdy is a consultant to Relypsa and Astra Zeneca. Dr Grams has a grant from the NKF. Dr Palmer reports receipt of consultancy and speaker fees from Relypsa and AstraZeneca. Full-Text PDF
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