医学
免疫系统
背景(考古学)
机制(生物学)
免疫学
慢性阻塞性肺病
肺
专家意见
免疫
重症监护医学
生物
内科学
古生物学
哲学
认识论
作者
Sadiya Bi Shaikh,Chiara Goracci,Ariel Tjitropranoto,Irfan Rahman
标识
DOI:10.1080/17476348.2023.2205127
摘要
Introduction Several immunological alterations that occur during pulmonary diseases often mimic alterations observed in the aged lung. From the molecular perspective, pulmonary diseases and aging partake in familiar mechanisms associated with significant dysregulation of the immune systems. Here, we summarized the findings of how aging alters immunity to respiratory conditions to identify age-impacted pathways and mechanisms that contribute to the development of pulmonary diseases,Areas covered The current review examines the impact of age-related molecular alterations in the aged immune system during various lung diseases, such as COPD, IPF, Asthma, and alongside many others that could possibly improve on current therapeutic interventions. Moreover, our increased understanding of this phenomenon may play a primary role in shaping immunomodulatory strategies to boost outcomes in the elderly. Here, the authors present new insights into the context of lung-related diseases and describe the alterations in the functioning of immune cells during various pulmonary conditions altered with age.Expert opinion The expert opinion provided the concepts on how aging alters immunity during pulmonary conditions, and suggests the associated mechanisms during the development of lung diseases. As a result, it becomes important to comprehend the complex mechanism of aging in the immune lung system.
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