To reveal the key mechanism of Citri Reticulatae Pericarpium–Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect with network pharmacology, molecular docking and bioinformatics

Survival analysis indicated that HSP90AA1 may serve as a potential biomarker for LC. Molecular docking studies showed that rhein, a compound in CR, has a strong binding affinity to the identified target proteins. This research provides robust theoretical support for the clinical application of CR in treating LC, especially in cases related to non-alcoholic fatty liver disease (NAFLD) or Metabolic Lipid Disorders (DLM).