Development of exosomes biogenesis and secretion mechanisms

Exosomes are nano-sized membrane vesicles (30-100nm in diameter) actively secreted by many cell types and generally exist in many body fluids that contain a variety of cargos, such as protein, lipid and nucleic acid. Exosomes play an important role in cross-communication between different cells and closely associate with the development, treatment and prognostic of many diseases. Recently, exosomes have becoming a hot spot in medical research. An overview of current understanding in biogenesis and secretion mechanism, as well as the regulation of exosomes has been laid in present paper. DOI: 10.11855/j.issn.0577-7402.2017.12.16