蛋白质稳态
未折叠蛋白反应
内质网
蛋白质聚集
神经科学
疾病
蛋白质折叠
机制(生物学)
平衡
生物
细胞生物学
医学
内科学
认识论
哲学
作者
Felipe Cabral‐Miranda,Claudio Hetz
出处
期刊:Current Topics in Microbiology and Immunology
日期:2017-01-01
卷期号:: 131-157
被引量:22
摘要
The accumulation of protein aggregates has a fundamental role in the patophysiology of distinct neurodegenerative diseases. This phenomenon may have a common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protein aggregation. The unfolded protein response (UPR) embodies a major element of the proteostasis network triggered by endoplasmic reticulum (ER) stress. Chronic ER stress may operate as possible mechanism of neurodegenerative and synaptic dysfunction, and in addition contribute to the abnormal aggregation of key disease-related proteins. In this article we overview the most recent findings suggesting a causal role of ER stress in neurodegenerative diseases.
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