生物
克隆(Java方法)
癌症的体细胞进化
肿瘤细胞
基因
肿瘤进展
遗传学
肿瘤
选择(遗传算法)
癌症研究
细胞
人工智能
计算机科学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1976-10-01
卷期号:194 (4260): 23-28
被引量:5850
标识
DOI:10.1126/science.959840
摘要
It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic variability within the original clone allowing sequential selection of more aggressive sublines. Tumor cell populations are apparently more genetically unstable than normal cells, perhaps from activation of specific gene loci in the neoplasm, continued presence of carcinogen, or even nutritional deficiencies within the tumor.
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