信号转导
肌醇
蛋白激酶A
细胞生物学
激酶
细胞外
受体
酶
生物化学
第二信使系统
生物
细胞表面受体
细胞内
磷脂
蛋白激酶C
化学
膜
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1986-07-18
卷期号:233 (4761): 305-312
被引量:5021
标识
DOI:10.1126/science.3014651
摘要
Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information in the form of a variety of extracellular signals across the membrane to regulate many Ca2+-dependent processes. At an early phase of cellular responses, the enzyme appears to have a dual effect, providing positive forward as well as negative feedback controls over various steps of its own and other signaling pathways, such as the receptors that are coupled to inositol phospholipid hydrolysis and those of some growth factors. In biological systems, a positive signal is frequently followed by immediate negative feedback regulation. Such a novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to our understanding of cell-to-cell communication.
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