Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF⋅MeCN

Abstract The generation and use of the highly potent oxidising agent HOF ⋅ MeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gas–liquid/liquid–liquid continuous flow procedures are reported.