新皮层
生物
小RNA
神经科学
颞叶
人脑
基因表达
中枢神经系统
核糖核酸
阿尔茨海默病
大脑皮层
基因
疾病
遗传学
病理
癫痫
医学
作者
Prerna Sethi,Walter J. Lukiw
标识
DOI:10.1016/j.neulet.2009.04.052
摘要
Micro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease. In these studies, miRNA array and Northern blot based tracking of specific miRNA abundances and decay kinetics in human neural (HN) cells in primary culture and in short post-mortem interval (PMI, ∼1 h) human brain tissues showed a limited stability and relatively short half-life (∼1–3.5 h) for specific brain-enriched miRNAs. In short PMI Alzheimer's disease (AD)-affected temporal lobe neocortex, miRNA-9, miRNA-125b and miRNA-146a were found to be significantly up-regulated, an effect that was not seen in several related neurological disorders. The results suggest (a) that unless specifically stabilized, certain brain-enriched miRNAs represent a rapidly executed signaling system employing highly transient effectors of CNS gene expression, and (b) that in AD temporal lobe neocortex specific brain miRNAs are significantly up-regulated in abundance and strongly correlate with the presence of AD-type neuropatholgical change.
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