Cascade Signal Amplification for DNA Detection

Bigger and bigger. A novel, isothermal DNA detection method has been developed that contains two successive amplifications and integrates both a protein enzyme and a DNA enzyme. The current detection limit is 1 pM. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z600336_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.