医学
心力衰竭
射血分数
内科学
利钠肽
心脏病学
脑利钠肽
接收机工作特性
曲线下面积
作者
Yoshihiko Seino,Aiko Ogawa,Teruyo Yamashita,Masato Fukushima,Kenichi Ogata,Hiroko Fukumoto,Teruo Takano
标识
DOI:10.1016/j.ejheart.2003.12.009
摘要
Measurement of brain natriuretic peptide (BNP) has become a potent diagnostic aid as a means of identifying patients with systolic or diastolic dysfunction. Due to better stability in circulating blood, we reasoned that measurement of N-terminal proBNP (NT-proBNP) may be a more discerning marker for the detection and evaluation of chronic heart failure.The relationships between plasma concentrations of NT-proBNP and BNP, and aetiology, New York Heart Association (NYHA) classification, and left ventricular ejection fraction (LVEF) were analyzed in 105 patients with chronic heart failure. Sixty-seven healthy volunteers were studied as the controls.Both NT-proBNP and BNP showed progressive increases (P<0.001) in proportion to the NYHA classification; the increment of NT-proBNP was larger than that of BNP. Elevated NT-proBNP significantly correlated with BNP (r=0.737, P<0.001). Receiver operating characteristics analysis to detect LVEF<40% showed similar values (area under the curve, AUC: NT-proBNP 0.754 vs. BNP 0.770), however, AUC to detect LVEF<50% tended to be greater for NT-proBNP than that for BNP (NT-proBNP 0.820 vs. BNP 0.794).NT-proBNP may be a more discerning marker for the detection and evaluation of heart failure than BNP.
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