心磷脂
衰老
细胞生物学
生物
纤维连接蛋白
老化
化学
分子生物学
生物化学
细胞
磷脂
遗传学
膜
作者
Palaniyappan Arivazhagan,Emi Mizutani,Michihiko Fujii,Dai Ayusawa
标识
DOI:10.1016/j.bbrc.2004.08.177
摘要
Lipids seem to have various roles in cellular senescence. We found that cardiolipin very sensitively inhibits growth of normal human fibroblasts, whereas other phospholipids do not at 100 times higher concentrations. Growth arrested cells showed morphology similar to those of normally senesced cells and strongly induced senescence-associated beta-galactosidase. Senescence markers such as the p21(waf1/sdi-1), fibronectin, and collagenase-I genes were significantly upregulated by cardiolipin. In addition, caldiolipin significantly increased in normally senesced human fibroblasts leaving other phospholipids unaltered. These results suggest that accumulation of cardiolipin is one of the causes for replicative senescence.
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