医学
红斑狼疮
系统性红斑狼疮
抗体
免疫学
自身抗体
狼疮性肾炎
作者
Andrew S. Lawrie,M. E. Lloyd,F. Mohamed,S. Irons,G. R. V. Hughes,G. F. Savidge
出处
期刊:Blood Coagulation & Fibrinolysis
[Ovid Technologies (Wolters Kluwer)]
日期:1995-06-01
卷期号:6 (4): 322-324
被引量:6
标识
DOI:10.1097/00001721-199506000-00005
摘要
Free protein S:Ag and protein S activity determined by clotting assay are often regarded as synonymous; however, in the study group of patients, abnormal protein S activity (PS:Act) results correlated poorly with abnormal free (PS:Ag(r2 = 0.164). Significantly none of the patients in whom lupus anticoagulant and low free protein S:Ag were detected were found to have low PS:Act. These results could not be explained by activated protein C resistance, suggesting that lupus anticoagulant may cause prolongation of the clotting time within the PS:Act assay and thus give falsely high results. As reduced levels of free protein S:Ag and/or protein S activity are considered risk factors of thrombosis in systemic lupus erythematosus, these findings question the suitability of the protein S activity assay for patients who may have phospholipid antibodies.
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