Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis

Triethylsilane was used as a scavenging agent in peptide synthesis for the removal of protecting groups with TFA. The efficiency of scavenging ability was compared with anisole and ethanedithiol in a kinetic experiment. It was also found that triethylsilane/TFA reduces the indole ring of tryptophan.