Do moisturizers work?

Summary Moisturizers are used on large body surfaces to maintain the smoothness of the skin and to break the dry‐skin cycle. Many healthcare professionals and patients overlook the importance of moisturizers and do not consider them to be ‘active’ treatments. However, evidence from clinical and experimental studies shows that moisturizers enhance both the smoothness and hydration of skin. Different moisturizers have different ingredients, and each may have a different mode of action. Some smooth the skin, others affect barrier function. Some enhance barrier function in both diseased and normal skin. Others impair barrier function in both diseased and normal skin. Defective barrier function may trigger the development of eczema. The composition of a particular moisturizer should reflect its desired therapeutic effect, i.e. a moisturizer to diminish dryness may need different ingredients from those required to improve barrier function. The content of excipients, such as emulsifiers, chelating agents and antioxidants, may have greater impact than is commonly believed. Greater tailoring of moisturizers will improve their efficacy. Confidence in the therapeutic effects of moisturizers will be enhanced by well‐designed randomized controlled trials.