Organocatalytic amination of alkyl ethers via n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp3)–N bond formation: novel synthesis of hemiaminal ethers

A novel method for constructing the hemiaminal ether framework under metal-free conditions has been developed. It involves direct organocatalytic amination of alkyl ethers through intermolecular oxidative C(sp³)–N bond formation, with t-BuOOH being the oxidant and n-Bu₄NI as the catalyst.