氟甲喹
丹诺沙星
色谱法
化学
培氟沙星
恶喹酸
甲酸
司帕沙星
氟罗沙星
洛美沙星
液相色谱-质谱法
检出限
串联质谱法
高效液相色谱法
质谱法
恩诺沙星
氧氟沙星
萘啶酸
环丙沙星
抗生素
生物化学
作者
Y L Li,Xingkai Hao,Baoqing Ji,Chuan Xu,W Chen,Chien-Chun Shen,Tao Ding
标识
DOI:10.1080/02652030802484851
摘要
A multiresidue method has been developed for the confirmation and quantification of 19 quinolones (enrofloxacin, ciprofloxacin, norfloxacin, ofloxacin, flumequine, oxolinic acid, difloxacin, sarafloxacin, sparfloxacin, danofloxacin, fleroxacin, marbofloxacin, enoxacin, orbifloxacin, pefloxacin, nalidixic acid, pipemidic acid, lomefloxacin and cinoacin) in pig and fish by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The samples were extracted with acetonitrile, analytes separated by LC on a C18 column using 0.1% formic acid–methanol with a linear gradient elution programme, and detected by MS/MS. The linear range was 0.3–50 µg kg–1 with correlation coefficients (r) more than 0.9956. The limits of detection were 0.1 µg kg–1. Mean recoveries for each analyte in pig muscle and fish ranged from 75.3% to 96.3% and from 79.7% to 94.2% with relative standard deviations below 10%. The method is fast, safe, sensitive and precise, and can be used simultaneously to analyse residual quinolones.
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