生殖系
生物
干细胞
细胞生物学
细胞分裂
卵黄发生
干细胞巢
神经干细胞
果蝇属(亚属)
细胞
卵母细胞
遗传学
胚胎
祖细胞
基因
作者
Leesa LaFever,Daniela Drummond‐Barbosa
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-08-12
卷期号:309 (5737): 1071-1073
被引量:299
标识
DOI:10.1126/science.1111410
摘要
Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.
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