生物利用度
药物输送
药品
吸收(声学)
剂型
治疗窗口
生化工程
药理学
风险分析(工程)
纳米技术
计算机科学
材料科学
医学
工程类
复合材料
作者
Rajendra Awasthi,Giriraj T. Kulkarni
出处
期刊:Drug Delivery
[Informa]
日期:2014-07-15
卷期号:23 (2): 378-394
被引量:52
标识
DOI:10.3109/10717544.2014.936535
摘要
A major constraint in oral controlled release drug delivery is that not all the drug candidates are absorbed uniformly throughout the gastrointestinal tract (GIT). Drugs having “absorption window” are absorbed in a particular portion of GIT only or are absorbed to a different extent in various segments of the GIT. Thus, only the drug released in the region preceding and in close vicinity to the absorption window is available for absorption. The drug must be released from the dosage form in solution form; otherwise, it is generally not absorbed. Hence, much research has been dedicated to the development of gastroretentive drug delivery systems that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs, as these systems have unique properties to bypass the gastric emptying process. These systems show excellent in vitro results but fail to give desirable in vivo performance. During the last 2–3 decades, researchers from the academia and industries are giving considerable importance in this field. Unfortunately, till date, few so-called gastroretentive dosage forms have been brought to the market in spite of numerous academic publications. The manuscript considers strategies that are commonly used in the development of gastroretentive drug delivery systems with a special attention on various parameters, which needs to be monitored during formulation development.
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