Microbiological Transformation of Steroid. VII. Hydroxylation of Steroid by Gibberella saubinetii ; 6β- and 15α-Hydroxylation.

Application of Gibberella soubinetii to various steroid showed the formation of 15α-hydroxylated compound from progesterone and deoxycorticosterone, and 6β-hydroxylated compound from Reichstein's compound S and 17α-hydroxyprogesterone. Corticosterone afforded, by this reaction, 15α-hydroxycorticosterone derivative with one tertiary hydroxyl, whose structure has not been determined. Fusarium lycopersici also showed the same reaction as Gibberella soubinetii.