酰肼
麻风病
异烟酸
质谱
激光器
化学
麻风分枝杆菌
肺结核
质谱法
分析化学(期刊)
分子生物学
色谱法
医学
免疫学
生物
病理
光学
有机化学
物理
作者
Ulrich Seydel,Buko Lindner,Seydel Jk,K Brandenburt
出处
期刊:PubMed
日期:1982-03-01
卷期号:50 (1): 90-5
被引量:1
摘要
Applying the laser microbe mass analyzer method (LAMMA), mass spectra (fingerprints) were taken from single bacterial cells not treated or treated with high temperature, X-irradiation, isonicotinic acid hydrazide (INH), or diaminodiphenylsulfone (DDS). Spectra of treated cells ("M. lufu," M. tuberculosis H37Ra, E. coli) differ from those of controls in that the K+/Na+ ratio was smaller and in that the intensities of peaks with m/e greater than 100 were lower. From the results with M. leprae the possible application of this new method for monitoring the effectiveness of leprosy therapy is proposed.
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