Specific Fluorescent Probe for 8‐Oxoguanosine

Marking mutations: Complete discrimination of 8-oxoguanosine (8-oxoG) from other nucleosides has been achieved with a new fluorescent probe, named "8-oxoG-clamp" (see picture). The complex structure between 8-oxoG-clamp and 8-oxoG was confirmed by 1H NMR titration and 2D NMR measurements. A preliminary investigation with use of a detergent for solubilization indicates that 8-oxoG-clamp may be applicable in aqueous media. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700671_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.