病理
脂肪肉瘤
间充质干细胞
融合基因
免疫组织化学
滑膜肉瘤
孤立性纤维性肿瘤
软组织
间充质软骨肉瘤
软骨肉瘤
肉瘤
粘液样脂肪肉瘤
生物
STAT6
癌症研究
医学
基因
转录因子
川地34
干细胞
细胞生物学
生物化学
作者
Giuseppe Broggi,Manuel Mazzucchelli,Renato Covello,Beatrice Casini,Giuseppe Barbagallo,Lucia Salvatorelli,Gaetano Magro
标识
DOI:10.1016/j.prp.2022.153803
摘要
STAT6 is usually considered to be a very sensitive and specific immunomarker for diagnosis of solitary fibrous tumor (SFT), being a surrogate of the NAB2-STAT6 fusion gene identified in most cases of this tumor. STAT6 expression has also been reported in rare cases of other soft tissue tumors, such as low-grade fibromyxoid sarcoma, myxoid/round cell liposarcoma, dedifferentiated liposarcoma and deep fibrous histiocytoma. The aim of this study was to report, for the first time, a case of mesenchymal chondrosarcoma showing diffuse aberrant immunohistochemical expression of STAT6. Molecular biology, showing the HEY1-NCOA2 fusion gene, was crucial to rule out SFT.
科研通智能强力驱动
Strongly Powered by AbleSci AI