替莫唑胺
医学
放射治疗
胶质母细胞瘤
化疗
免疫疗法
疾病
肿瘤科
脑瘤
癌症
重症监护医学
内科学
病理
癌症研究
作者
Asraa Faris Aldoghachi,Ahmed Faris Aldoghachi,Koen Breyne,King‐Hwa Ling,Pike-See Cheah
出处
期刊:Neuroscience
[Elsevier BV]
日期:2022-04-05
卷期号:491: 240-270
被引量:66
标识
DOI:10.1016/j.neuroscience.2022.03.030
摘要
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest malignant types of primary astrocytoma with a poor prognosis. At present, the standard of care includes surgical tumor resection, followed by radiation therapy concomitant with chemotherapy and temozolomide. New developments and significant advances in the treatment of GBM have been achieved in recent decades. However, despite the advances, recurrence is often inevitable, and the survival of patients remains low. Various factors contribute to the difficulty in identifying an effective therapeutic option, among which are tumor complexity, the presence of the blood-brain barrier (BBB), and the presence of GBM cancer stem cells, prompting the need for improving existing treatment approaches and investigating new treatment alternatives for ameliorating the treatment strategies of GBM. In this review, we outline some of the most recent literature on the various available treatment options such as surgery, radiotherapy, cytotoxic chemotherapy, gene therapy, immunotherapy, phototherapy, nanotherapy, and tumor treating fields in the treatment of GBM, and we list some of the potential future directions of GBM. The reviewed studies confirm that GBM is a sophisticated disease with several challenges for scientists to address. Hence, more studies and a multimodal therapeutic approach are crucial to yield an effective cure and prolong the survival of GBM patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI