A Patient With Polyuria and Hypercalcemia

A 34-year-old woman with a medical history of migraines and bipolar disorder is referred to nephrology clinic for elevated serum creatinine and polyuria. In clinic, she states she has had “constant” urination for the past year, noting that she urinates almost 15 times daily, including 3 episodes of nocturia. She drinks nearly 100 ounces of water daily, which is driven by her perpetual thirst. She otherwise describes her diet as “typical,” and does not consume abnormal amounts of sodium or protein.