依维莫司
涂层
PLGA公司
生物医学工程
支架
药物洗脱支架
材料科学
医学
外科
纳米技术
内科学
再狭窄
纳米颗粒
作者
Dimitrios S. Pleouras,Georgia S. Karanasiou,Vasileios S. Loukas,Arsen Semertzioglou,Anargyros N. Moulas,Dimitrios I. Fotiadis
标识
DOI:10.1109/embc46164.2021.9629813
摘要
This case-study examines the release time of the everolimus drug from an experimental biodegrading coating of a Rontis corp. drug eluting stent (DES). The controlled drug release is achieved by the degradation of the coating, which consists of a mixture of polylactic co-glycolic acid (PLGA) and everolimus (55:45). In our analysis, we used the outcome of another study, which contains the geometry of an in-silico deployed Rontis corp. stent in a 3D reconstructed coney arterial segment. Using this geometry as input, the everolimus release was simulated using a computational model that includes: i) modeling of the blood flow dynamics, ii) modeling of PLGA degradation, and iii) modeling of the everolimus advection and diffusion towards both the lumen and the arterial wall. The results show the rapid release of everolimus. This is justified due to the high porosity of the coating, which is caused by the initial high concentration of everolimus in the coating.Clinical Relevance — The methodology presented in this work is an additional step towards predicting accurately drug release from DES. Also, the results of our work prove that high drug concentration in the coating causes its rapid release, which could be used as input in the design of new DES.
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