立体选择性
萘醌
化学
钯
催化作用
取代基
赫克反应
基础(拓扑)
组合化学
偶联反应
有机化学
药物化学
立体化学
数学
数学分析
作者
Dora L. Costa,Luana da S. M. Forezi,Milena D. Lessa,Maicon Delarmelina,Beatriz V. A. Matuck,Maria João Freitas,Vitor F. Ferreira,Jackson A. L. de C. Resende,José Walkimar de M. Carneiro,Fernando de C. da Silva
标识
DOI:10.1002/slct.202201334
摘要
A stereoselective, base-free Heck coupling between 1,4-naphthoquinone and 1H-1,2,3-triazole derivatives was reported for the first time. This study shows that depending on the 1,4-naphthoquinone, the use of an additional base is unnecessary to produce the naphthoquinone-triazole conjugates. This is also the first example of a Heck coupling of these two cores without using a base as an additive. In this work, sixteen new naphthoquinone-triazole hybrids were stereoselectively synthetized in good to excellent yields. The reaction mechanism was discussed based on DFT CAM−B3LYP calculations. The first step is the coordination of the arene to the palladium catalyst to form a palladacycle intermediate. After reorganization in this intermediate, the double bond in the arene is restored to proceed with the coupling step and formation of the C−C bond in the rate determining step. The Kozuchi-Shaik span model was employed to rationalize substituent effects.
科研通智能强力驱动
Strongly Powered by AbleSci AI