PI3K/AKT/mTOR通路
自噬
蛋白激酶B
信号转导
赫拉
癌症研究
细胞生物学
RPTOR公司
细胞凋亡
药物发现
化学
生物
生物信息学
细胞
生物化学
作者
Driss Boutat,Xun Wang,Zhenzhen Du,Jiali Liu,Yue Zhong,Qingyu Tian
标识
DOI:10.1109/bibm52615.2021.9669786
摘要
Human papillomavirus (HPV) infection is linked to several diseases, the most prominent of which are cervical cancer and genital condyloma acuminatum. PI3K-Akt-mTOR signaling pathway is one of the most important signaling pathway in the regulation of proliferation, differentiation and apoptosis of human cervical cancer cells, and this pathway has the potential to become a novel target for the development of cervical cancer therapeutics. Previous studies have suggested that drug therapy can modulate PI3K-AKT-mTOR pathway to reduce HPV viral load effectively through autophagy and apoptosis. Therefore, in our study, in order to find drugs that can regulate this pathway, we collected more than 20 proteins related to this pathway and used deep learning models to predict protein-ligand binding affinity, finally listed the drug molecules with the highest predicted affinity score for each protein molecule.
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