Translational research continues to be an underinvestigated area of science. One discipline that has had scant attention by those who practice translational research is neuroanatomy. As a clinician and neuroanatomist, the author has experienced success with a reverse translational research model. This paradigm identifies surgical problems and in the anatomy laboratory, investigates ways of answering these issues. The goal of such research is to improve patient outcomes in an expedited manner. The author reviews his 20 year experience with identifying common neurosurgical issues and addressing them with neuroanatomical investigation.