CD30
淋巴瘤
外周T细胞淋巴瘤
病理
医学
经典霍奇金淋巴瘤
淋巴结
爱泼斯坦-巴尔病毒
病毒
霍奇金淋巴瘤
T细胞淋巴瘤
淋巴增殖性病變
间变性大细胞淋巴瘤
上皮样细胞
T细胞
免疫学
免疫组织化学
霍奇金淋巴瘤
免疫系统
作者
Kuniyuki Oka,Reizo Nagayama,Shigeruko Iijima,Nobuo Yonekawa,K Hirosawa,Yasushi Yatabe,Naoyoshi Mori
标识
DOI:10.1111/j.1440-1827.2011.02723.x
摘要
We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67-years-old and peripheral T-cell lymphoma, not otherwise specified (PTCL) at 76-years-old, and died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed with neoplastic cells. Hodgkin and Reed-Sternberg cells in the swollen lymph node were positive for CD30 and EBV-encoded RNA (EBER). PTCL cells in the skin tumor were positive for cytoplasmic CD3ε, CD4 and EBER. A rearrangement band of the T-cell receptor gene was detected in the skin tumor. This case is the first documented EBV-associated composite lymphoma composed of CHL and PTCL. The patient may show the possibility that both EBV infection and/or immunodeficiency induce the development of CHL and PTCL.
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