免疫系统
生物
适应(眼睛)
人口
获得性免疫系统
细胞
适应性
炎症
免疫学
细胞生物学
神经科学
遗传学
医学
生态学
环境卫生
作者
Theodora Agalioti,Filippo Cortesi,Nicola Gagliani
标识
DOI:10.1016/j.coi.2023.102333
摘要
At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment. We would like to term this process environmental immune adaptation. Interfering with TH17 cell adaptation leads to pathological consequences, including development of immune-mediated inflammatory diseases or even cancer. Several molecular mechanisms have been shown to participate in this process and recently, a better understanding of the transcriptional and metabolic profiling of TH17 cells has shed light on a new level of complexity. Here, we offer a summary on the role of TH17 cell plasticity in inflammatory diseases and cancer as well as the latest discoveries and controversies regarding the mechanisms that control the adaptability of the TH17 cell population.
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