Patient: A 67-year-old woman presented with severe periodontitis-induced terminal dentition and proclined maxillary incisor. Three-dimensional facial esthetics-driven computer-assisted virtual tooth rearrangement was performed for implant-supported full-arch reconstruction. The digital workflow combines facial and spiral computed tomography (CT) scans to generate a virtual patient for three-dimensional (3D) facial analysis and obtain a visual treatment objective (VTO)-based lateral esthetic preview for virtual teeth rearrangement. Subsequently, this printed interim denture performed well in functionalization and esthetics, acted as a transitional removable denture, radiological template, and implant-supported interim denture, and guided the design of the final restoration.