鼻咽癌
队列
内科学
医学
极低密度脂蛋白
肿瘤科
置信区间
队列研究
脂蛋白
多中心艾滋病队列研究
危险分层
肝细胞癌
胃肠病学
病毒
免疫学
胆固醇
病毒载量
放射治疗
抗逆转录病毒疗法
作者
ZHOU Zhenhua,Tao Tang,Nan Li,Qiaocong Zheng,Ting Xiao,Yunming Tian,Jianda Sun,Longshan Zhang,Xiaoqing Wang,Yingqiao Wang,Feng Ye,Zekai Chen,Hanbin Zhang,Xiuting Zheng,Zhen Cai,Laiyu Liu,Jian Guan
标识
DOI:10.1002/advs.202308765
摘要
Abstract Serological tests for Epstein–Barr virus (EBV) antibodies have been widely conducted for the screening of nasopharyngeal carcinoma (NPC) in endemic areas. Further risk stratification of NPC can be achieved through plasma lipoprotein and metabolic profiles. A total of 297 NPC patients and 149 EBV‐positive participants are enrolled from the NCT03919552 and NCT05682703 cohorts for plasma nuclear magnetic resonance (NMR) metabolomic analysis. Small, dense very low density lipoprotein particles (VLDL‐5) and large, buoyant low density lipoprotein particles (LDL‐1) are found to be closely associated with nasopharyngeal carcinogenesis. Herein, an NMR‐based risk score (NRS), which combines lipoprotein subfractions and metabolic biomarkers relevant to NPC, is developed and well validated within a multicenter cohort. Combining the median cutoff value of the NRS (N 50 ) with that of the serological test for EBV antibodies, the risk stratification model achieves a satisfactory performance in which the area under the curve (AUC) is 0.841 (95% confidence interval: 0.811‐0.871), and the positive predictive value (PPV) reaches 70.08% in the combined cohort. These findings not only suggest that VLDL‐5 and LDL‐1 particles can serve as novel risk factors for NPC but also indicate that the NRS has significant potential in personalized risk prediction for NPC.
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