Two Sides of the Coin: Synthesis and Applications of Janus Particles

Named after the two-faced Roman god, Janus particles (JPs) are defined by their distinct dual chemical compositions on a single particle. Research on micron-sized JPs has yielded remarkable insights, showcasing their unique assembly behaviors both in bulk and at interfaces. However, significant challenges persist, particularly in the synthesis of smaller (<500 nm) JPs, which remains complex and difficult to scale up. To date, there has been no commercial success with JPs. Recently, seeded synthesis methods, such as emulsion polymerization that is already employed in industrial-scale manufacturing, have shown great promise. These methods enable the production of high-quality JPs with different sizes, morphologies, and functionalities. This advancement has inspired more efforts in exploring JP applications across various fields, including emulsion stabilization, drug delivery, electronic devices, and coatings. This review provides a comprehensive overview of the recent progress in the synthesis and application of polymeric JPs, with an emphasis on the seeded synthesis approach. It discusses the underlying reaction mechanisms and explores different strategies for controlling JP morphology. Serving as a roadmap, this review aims to guide the design of novel functional JPs and their potential future applications. The successful implementation of JPs will require careful consideration and a deep understanding of both synthesis and applications, as these are indeed two sides of the same coin.