没食子酸
芦丁
神经保护
化学
体外
药理学
生物化学
褪黑素
医学
抗氧化剂
内科学
作者
Anna Lia Asti,S. Crespi,Teresa Rampino,Paola Zelini,Marilena Gregorini,Alessia Pascale,Nicoletta Marchesi,Stefania Saccucci,C. Colombani,Sara Vitalini,Marcello Iriti
标识
DOI:10.1080/14786419.2023.2192493
摘要
A major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. Natural compounds are capable of binding to different targets implicated in AD and exert neuroprotective effects. Aim of this study was to evaluate the in vitro inhibition of Aβ1-42 fibrillogenesis in presence of Gallic acid, Rutin, Melatonin and ProvinolsTM . We performed the analysis with Transmission and Scanning Electron Microscopy, and with X-ray microanalysis. Samples treated with Rutin, that arises from phenylalanine via the phenylpropanoid pathway, show the best effective result obtained because a significantly fibril inhibition activity is detectable compared to the other compounds. Melatonin shows a better inhibitory activity than ProvinolsTM and Gallic acid at the considered concentrations.
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