Based on social cognition theory and social exchange theory, this paper constructs a model of the relationship between humble leadership and employee helping behavior, and discusses the mediating role of employee psychological security and the moderating role of defensive regulatory focus.On the basis of reliability and validity analysis, a structural equation model, Bootstrap and hierarchical regression analysis were used to analyze the data.The empirical results show that humble leadership has a significant positive impact on employee helping behavior, psychological security plays a mediating role between humble leadership and employee helping behavior, and defensive regulatory focus significantly moderates the relationship between humble leadership and employee helping behavior Keywords-Humble leadership; Employee helping behavior; Psychological security; Defensive adjustment focus