Sodium Alginate Launches MOF Defective Structures to Rapidly Construct Highly AChE‐Like Nanozyme for Neuroprotection

of ZIF-8, acted synergistically to form a bifunctional catalytic active site that enhances hydrolytic activity. Meanwhile, SA mediates the rapid formation of mesoporous architectures, improving substrate accessibility and mass transfer efficiency. In addition, 29-ZIF-8/SA demonstrates excellent environmental stability under harsh conditions and resists the inhibitory effect of methyl parathion (MP) on AChE activity. In vitro and in vivo experiments show that the 29-ZIF-8/SA composite exhibits cytoprotective properties to effectively attenuate MP-induced neurotoxicity. This work not only presents a designable method for the construction of highly active hydrolases, which are rarely reported, but also offers a new approach for nanozymes-based treatment of acute OP poisoning.