生物
生物钟
昼夜节律
背景(考古学)
时钟
基因
遗传学
分子钟
功能(生物学)
转录因子
神经科学
计算生物学
进化生物学
系统发育学
古生物学
作者
Nozomu Takahashi,Motomu Endo
出处
期刊:Development
[The Company of Biologists]
日期:2025-09-15
卷期号:152 (18)
摘要
ABSTRACT The plant circadian clock aligns developmental processes with environmental cycles, a function traditionally attributed to a unified, systemic oscillator. However, this view is challenged by observations that mutations in specific clock genes can cause major developmental phenotypes without a proportional disruption to systemic rhythms. This Hypothesis proposes that clock genes perform dual roles: they act not only as components of the systemic oscillator that generates rhythmicity, but also as specific, context-dependent regulators that control the timing of key developmental events. We argue that this gene-centric perspective extends and refines the classical oscillator model, positing that the pleiotropic nature of clock genes reflects their evolutionary history, whereby transcription factors with pre-existing developmental roles were co-opted for timekeeping. Understanding this functional duality – how individual clock components are deployed in specific tissues and conditions – offers a new perspective for dissecting the complex interplay between timekeeping and development.
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