Effectiveness of Yiqi Chupi powder for alleviating cancer-related fatigue in patients following colorectal cancer surgery: a randomized controlled trial.

OBJECTIVE: To evaluate the efficacy of Yiqi Chupi powder (, YQCPP) in reducing cancer-related fatigue (CRF) among patients with colorectal cancer (CRC) undergoing chemotherapy. METHODS: This was a prospective, randomized controlled trial. Eligible patients were randomly assigned to either the experimental group, receiving a 12-week regimen of YQCPP and capecitabine plus oxaliplatin (XELOX) chemotherapy, or the control group, receiving a 12-week XELOX chemotherapy alone. Outcome measures were collected at baseline and subsequently at weeks 3, 6, 9, and 12 of the treatment period. The primary outcome was the Piper Fatigue Scale (PFS) score. The secondary outcomes were the Traditional Chinese Medicine syndrome and Karnofsky Performance Status (KPS) scores. RESULTS: 0.05) at 6, 9, and 12 weeks. There was a significant improvement in overall quality of life at weeks 9 and 12 in the experimental group. CONCLUSION: YQCPP may decrease the CRF and improve quality of life in patients with CRC undergoing chemotherapy.