癌症研究
肿瘤微环境
T细胞
材料科学
免疫系统
嵌合抗原受体
实体瘤
细胞
免疫疗法
细胞疗法
过继性细胞移植
内化
联合疗法
医学
免疫学
抗原呈递
免疫检查点
靶向治疗
复归
作者
Chunxiong Zheng,Ke Yi,Yongkang Du,Qingguo Zhong,Huimin Kong,Haixia Wang,Enguo Ju,Yeh‐Hsing Lao,Xi Xie,Haochen Yao,Yu Tao,Mingqiang Li
标识
DOI:10.1002/adma.202510842
摘要
PPA peptide presentation enables T cells to overcome tumor cells' immune tolerance through PD-L1 checkpoint blockade. In a murine solid tumor model, IMPACTFUL-engineered T cells infiltrate tumors more effectively, resist exhaustion, and induce a more pro-inflammatory TME, leading to significantly suppressed tumor growth compared to unmodified T cells. Together, IMPACTFUL can empower adoptive T cell therapy by endowing T cells with multiple complementary functions in a single step. This approach offers a versatile platform to improve the therapeutic outcomes of T cell therapies against solid tumors and can accelerate their translation to clinical settings.
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